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Original Research Article | OPEN ACCESS

Inhibitory effect of platinum (II) complex of curcumin on non-small cell lung cancer via the PI3K-AKT pathway

Yu Wang, Chen Li

Molecular Testing Center, The First Affiliated Hospital of Jinzhou Medical University, JinZhou 121000, Liao Ning Province, China;

For correspondence:-  Chen Li   Email: re1162@163.com   Tel:+8613841629131

Accepted: 28 August 2018        Published: 30 September 2018

Citation: Wang Y, Li C. Inhibitory effect of platinum (II) complex of curcumin on non-small cell lung cancer via the PI3K-AKT pathway. Trop J Pharm Res 2018; 17(9):1771-1776 doi: 10.4314/tjpr.v17i9.13

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the effect of platinum (II) complex of curcumin (PCC) on non-small cell lung cancer (NSCLC) using human NSCLC cell line A549. 
Methods: The anti-proliferative and apoptotic effects of PCC against NSCLC were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Annexin V-FITC/propidium iodide double staining, quantitative real-time polymerase chain reaction (qRT-PCR), and western blot assays.
Results: First, MTT assay and Annexin V-FITC/propidium iodide double staining results revealed that PCC possesses strong anti-cancer potency and high safety, when compared with cisplatin. Western blotting and qRT-PCR results showed that PCC inhibited the viability of NSCLC cells, decreased the expressions of PI3K, VEGF, AKT and Bcl-2, and upregulated the expression of PTEN.
Conclusion: These results indicate that PCC promotes apoptosis in A549 cells via PTEN/PI3K/AKT signaling pathways.

Keywords: Platinum-curcumin complex, Non-small cell lung cancer, Apoptosis, PI3K-AKT

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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